HYDROACOUSTICS
ANNUAL JOURNAL
START NEW VOL 20 SEARCH STATISTICS PAS - GDANSK DIVISION

Automated bimodal ultrasound device for preclinical testing of HIFU technique in treatment of solid tumors implanted into small animals

pp. 93-98, vol. 20, 2017

Tamara Kujawska
Institute of Fundamental Technological Research of the Polish Academy of Sciences, Poland

Wojciech Dera
Institute of Fundamental Technological Research of the Polish Academy of Sciences, Poland

Cezary DziekoƄski
Institute of Fundamental Technological Research of the Polish Academy of Sciences, Poland

Key words: High Intensity Focused Ultrasound beam; focal volume; tissue damage

Abstract: In Poland cancer is the second cause of death overall, and the first before 65. Demand for new anticancer therapies is increasing every year. The main objective of studies on medical and technical aspects of new anticancer methods is to reduce unwanted side effects and costs associated with conventional methods of treatment. Percutaneous (noninvasive) HIFU (High Intensity Focused Ultrasound) technique gives the chance to radically reduce both of these factors. The main goal of this work is automation of HIFU technology for producing thermal damage to the entire volume of a solid breast tumor implanted into a rat mammary gland using the proposed bi-modal ultrasound equipment, enabling the ultrasonic heating of a small volume within the tumor under the ultrasonic imaging control, as well as 3D scanning of the heating beam focus throughout the entire tumor volume. Design of the proposed equipment includes the heating probe of low frequency (about 1MHz), allowing penetration of pulsed focused waves into tissues, and the linear phased array probe of high frequency (from 4 MHz to 10 MHz), allowing visualization of the locally heated area inside the tumor in real time. Automatic 3D scanning of the heating beam focus provides the thermal damage to its entire volume.

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© Polish Acoustical Society - Gdansk Department, Polish Academy of Sciences. This work is licensed under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported. (CC BY-NC-SA 3.0)