HYDROACOUSTICS
ANNUAL JOURNAL
START NEW VOL 19 SEARCH STATISTICS PAS - GDANSK DIVISION

Generation and measurement of acoustic streaming in limited space

pp. 361-368, vol. 19, 2016

Wojciech Secomski
Department of Ultrasound, Institute of Fundamental Technological Research, Polish Academy of Sciences, Poland

Andrzej Nowicki
Department of Ultrasound, Institute of Fundamental Technological Research, Polish Academy of Sciences, Poland

Key words: ultrasound; radiation force; blood; thrombolysis

Abstract: The aim of this work was to use the streaming phenomena to assist clot dissolution in blood vessel. Such treatment is called sonothrombolysis. Acoustic streaming is a steady flow in a fluid driven by the acoustic wave propagating in a lossy medium. It is a non-linear effect and it depends on ultrasound intensity, and sound absorption in the media. The source of ultrasound was a flat piezoceramic disc generating long pulses at 1 MHz frequency and 0.2 W/cm2 ITA acoustical intensity. The streaming was generated in a vessel simulating free space, and next repeated in a multi-well cell culture plate, and in the limited space inside the 8 mm diameter silicone tube positioned perpendicular to the ultrasonic beam. The tube was filled with a mixture of water, glycerol, and starch, so with acoustic properties similar to blood. The streaming velocity was recorded either by the Siemens Acuson Antares ultrasonic scanner operating in the color Doppler mode at 8.9 MHz, or by the custom built 20 MHz pulsed Doppler flowmeter. The results obtained using both systems were very similar. The recorded streaming velocities were 3.2 cm/s, 6.1 cm/s and 0.3 cm/s, respectively. They were an order of magnitude smaller than that calculated theoretically. However, the results obtained confirm existence of streaming, even very close to the source, in the limited space. This effect will be explored in in-vitro experiments of blood clot dissolution within the tube simulating a blood vessel.

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© Polish Acoustical Society - Gdansk Department, Polish Academy of Sciences. This work is licensed under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported. (CC BY-NC-SA 3.0)