Abstract: Acoustocerebrography (ACG) is a set of techniques designed to capture states of human brain tissue, and its changes. It is based on noninvasive measurements of various parameters obtained by analyzing an ultrasound pulse emitted through the human’s skull. ACG and Magnetic Resonance Imaging (MRI) results were compared in a clinical study assessment of focal white-matter-lesions (WML) in the brains of patients with asymptomatic atrial fibrillation (AAF). The clinical study included 55 patients (age 66.1 ± 6.7 years). According to MRI data, the patients were assigned into four groups depending on the number of lesions: L0 - 0 to 4 lesions, L5 - 5 to 9 lesions, L10 - 10 to 29 lesions, and L30 - 30 or more lesions. As a result, it has been concluded that the ACG method could clearly differentiate the groups L0 (with 0 ÷ 4 lesions) and L30 (with more than 30 lesions) of WML patients. Fisher’s Exact Test shows that this correlation is highly significant (p < 0.001). ACG seems to be a new, effective, method for detecting WML for patients with AAF and can become increasingly useful in both diagnosing, and in stratifying, them. This, in turn, can be helpful in individualizing their treatment, so that the risk of strokes may become essentially reduced.