Abstract: Nowadays there are new modalities in ultrasound imaging allowing better characterization of tissue regions with different stiffness. We are proposing a novel approach based on compression and rarefaction of tissue simultaneously with imaging. The propagating wave is a combination of two pulses. A low frequency pulse is expected to change the local scattering properties of the tissue due to compression/rarefaction while a high frequency pulse is used for imaging. Two transmissions are performed for each scanning line. First, with the imaging pulse that propagates on maximum compression caused by a low frequency wave. Next, the low frequency wave is inverted and the imaging pulse propagates over the maximum rarefaction. After the processing of the subtracted echoes from subsequent transmissions including wavelet transform and band-pass filtering, differential images were reconstructed. The low frequency wave has a visible impact on the scattering properties of the tissue which can be observed on a differential image.