Abstract: The scattering of ultrasonic waves depends on the size, shape, acoustical properties and concentration of scatterers in tissue. In these study K distribution of the ultrasound backscatter envelope was used to assess the structural properties of the skin tissue. The custom-designed high frequency ultrasonic scanner was applied to obtain RF B-scans of the skin in vivo at the frequency of 20 ÷ 30MHz. The results are encouraging. The K distribution models the envelope statistics very well. The parameters of the K-distribution, namely, the effective number of scatterers may be useful for the skin characterization.