Abstract: The new approach on estimation of the coordinates of moving acoustic source in inhomogeneous medium with a strong scattering is discussed. The foundation of new approach is the speckle-interferometry methods (SIM), based on correlation features of multi-wave or scattered angle spectrums. It is shown that SIM can provide the same angle (linear) resolution in inhomogeneous medium as for free space. Same results of computer simulation and experiments are presented. In the first group of experiments the High-Speed 2D-Imaging Ultrasound Camera was used on frequency 1 MHz in water layer with a strong scattering screen in front of acoustical lens. In the second case the trajectory of drilling profile has been reconstructed by SIM processing of low-frequency signals (15-90) Hz, generated by rotator bit, and received by two crossed linear arrays. The results of SIM procedures are compared with the profile estimated before by inclinometers.